JEREMIAH J. TWOMEY, M.D.
To the editor: I have read with interest the report by Hughes and associates (Ann Intern Med 74:903-910, 1971) on their studies of small-bowel disease in immunoglobulin-deficient patients. They found a high prevalence of nodular lymphoid hyperplasia and evidence of sprue among the six patients studied. They postulated that infection may be the major pathogenetic factor in small bowel disease in Ig-deficient patients.
This study also confirms our earlier observation that there is a high prevalence of gastric atrophy in Ig-deficient patients (1, 2). The fact that both their and our patients had an idiopathic delayed-onset type of Ig deficiency
TWOMEY JJ. Immunoglobulin and Gut Disease. Ann Intern Med. ;75:970–971. doi: 10.7326/0003-4819-75-6-970
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Published: Ann Intern Med. 1971;75(6):970-971.
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