SANDOR A. FRIEDMAN, M.D.; ALBERT E. RAIZNER, M.D.; HERMAN ROSEN, M.D., F.A.C.P.; NATHAN A. SOLOMON, M.D., Ph.D.; WILFREDO SY, M.D.
Characteristics of the aging process as it affects renal function were studied in 35 elderly persons without renal disease or hypertension. Mean age was 75 years, with a range of 60 to 93 years. Radioisotope scans of the kidneys were abnormal in 25 patients (71%), with 16 of them (46%) showing focal areas of diminished uptake. There was a discrepancy between the relatively normal anatomical kidney size, as determined by excretory urography, and the functional size, measured by scanning. The mean creatinine clearance in 21 patients was low (53 ml/min ± 10 SD), but significant proteinuria was absent. Deterioration of renal function seen with aging is apparently an asymmetric process that is unrelated to intrinsic glomerular disease and spares kidney size. The mechanism is still speculative, but vascular insufficiency might explain these features. Since there is no Pyelographic evidence of space-occupying lesions, the focal scan defects may represent ischemic areas where tubular function is sharply reduced.
FRIEDMAN SA, RAIZNER AE, ROSEN H, SOLOMON NA, SY W. Functional Defects in the Aging Kidney. Ann Intern Med. ;76:41–45. doi: 10.7326/0003-4819-76-1-41
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Published: Ann Intern Med. 1972;76(1):41-45.
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