EDWARD T. WONG, M.D.; RICHARD P. DOE, M.D., Ph.D.
The long-acting thyroid stimulator (LATS) has been said to be the pathogenetic factor of the thyroid autonomy or hyperfunction in Graves' disease. Two patients had the ophthalmopathy and pretibial myxedema of Graves' disease occurring with Hashimoto's thyroiditis. Both patients had suppressed thyroid function in response to exogenous thyroid hormone in spite of the presence of high levels of LATS in their serums. The long-acting thyroid stimulator may not be the cause of the fixed thyroid function of Graves' disease.
WONG ET, DOE RP. Suppressibility of Thyroid Function Despite High Levels of Long-Acting Thyroid Stimulator. Ann Intern Med. ;76:77–84. doi: 10.7326/0003-4819-76-1-77
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Published: Ann Intern Med. 1972;76(1):77-84.
Endocrine and Metabolism, Thyroid Disorders.
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