CURTIS B. WILSON, M.D., F.A.C.P.; ROBERT C. SMITH, M.D.
A woman developed severe hemoptysis and glomerulonephritis (Goodpasture's syndrome) in association with an apparent influenza A2 virus infection. The proliferative glomerular lesion contained immunofluorescent deposits of immunoglobulin and complement in a linear pattern along the glomerular basement membrane (GBM), suggesting the presence of anti-GBM antibodies. The pulmonary and renal functional abnormalities rapidly diminished and were absent on examination 5 years after the original illness. This suggested that the response was short-lived and may have been triggered by a transient, virally associated antigenic stimulus.
WILSON CB, SMITH RC. Goodpasture's Syndrome Associated with Influenza A2 Virus Infection. Ann Intern Med. ;76:91–94. doi: 10.7326/0003-4819-76-1-91
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Published: Ann Intern Med. 1972;76(1):91-94.
Autoimmune Kidney Disease, Infectious Disease, Nephrology, Pulmonary/Critical Care, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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