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Hepatic encephalopathy is one of the most disabling complications of advanced cirrhosis and the commonest complication of porta systemic shunt surgery. Although the major deficit leading to encephalopathy relates to the inability of the liver to handle ammonia metabolism, there are many other factors that play a role in the development of coma that, therefore, must be considered in its treatment. Drs. Steigman and Clowdus present a thorough and well-referenced discourse on this subject. The text includes chapters devoted to the pathogenesis, central nervous system changes, and clinical manifestation of encephalopathy. It ends with a discussion of problems in diagnosis,
Hepatic Encephalopathy.. Ann Intern Med. ;76:150. doi: 10.7326/0003-4819-76-1-150_1
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Published: Ann Intern Med. 1972;76(1):150.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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