FRED PLUM, M.D.
Since the 19th century, when Cheyne (1818) first noted periodic breathing and Biot (1876) dubbed ataxic breathing "meningitic," perceptive clinicians have recognized that abnormal respiratory patterns can reflect serious dysfunction of the brain and often imply a poor prognosis. Rout, Lane, and Wollner (1) have recently refocused attention on these important principles in studies of patients with strokes, supplementing graphs of the abnormal breathing patterns with analyses of the respiratory gases and acid-base balance in the blood and cerebrospinal fluid. Patients with normal respiratory patterns and blood gases survived, while those with Cheyne-Stokes breathing or hyperventilation fared badly: out of
PLUM F. Hyperpnea, Hyperventilation, and Brain Dysfunction. Ann Intern Med. ;76:328. doi: 10.7326/0003-4819-76-2-328
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Published: Ann Intern Med. 1972;76(2):328.
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