J. A. LEVI, M.B.; P. C. VINCENT, M.B.; F. W. GUNZ, M.D., Ph.D.
Twenty-two adult patients with acute nonlymphoblastic leukemia were treated with a regimen consisting of an initial priming dose of hydroxyurea for the first induction course, followed by intermittent courses of cytosine arabinoside, given subcutaneously, and thioguanine. Fifteen of these patients achieved a remission; 9 were complete and 6 partial. The median survival time from diagnosis for all patients was 21.5 weeks, the median remission time was 15 weeks, and the median survival time for those patients who responded to therapy was 34 weeks. Toxic effects were generally not severe, the most disturbing being nausea and vomiting. The subcutaneous use of cytosine arabinoside was well tolerated by the patients and gave results comparable to those reported in series where it was given intravenously. This study confirms the experience of others that cytosine arabinoside in combination with another drug gives better results than when used alone.
LEVI JA, VINCENT PC, GUNZ FW. Combination Chemotherapy of Adult Acute Nonlymphoblastic Leukemia. Ann Intern Med. ;76:397–403. doi: 10.7326/0003-4819-76-3-397
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Published: Ann Intern Med. 1972;76(3):397-403.
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