RICHARD S. KRONENBERG, M.D.; PHILLIPPE L'HEUREUX, M.D.; RICHARD A. PONTO, B.A.; CHARLES W. DRAGE, M.D.; MERLE K. LOKEN, M.D., Ph.D.
The effect of age on the uniformity of lung perfusion was studied, using intravenous injections of 99mTc-labeled albumin microspheres, in a group of 30 normal men with a mean age of 69.6 years. Uniformity was assessed by computer-generated contour plots, photoscintigrams, and chest X rays. The results were compared with similar data obtained from young normal subjects and patients with chronic obstructive lung disease. Both the contour plots and photoscintigrams provided statistically significant differentiation among the three groups of subjects, but the contour plots were more discriminating. None of the normal subjects were judged abnormal by the contour plot technique. Lung perfusion in the old normal subjects was uniform and closely resembled that seen in the young normal subjects. The finding of perfusion defects in photoscintigrams of patients over 50 years of age cannot be presumed to be a consequence of age but probably represents significant pulmonary abnormality.
KRONENBERG RS, L'HEUREUX P, PONTO RA, DRAGE CW, LOKEN MK. The Effect of Aging on Lung Perfusion. Ann Intern Med. 1972;76:413–421. doi: 10.7326/0003-4819-76-3-413
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Published: Ann Intern Med. 1972;76(3):413-421.
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