JACOB CHURG, M.D.; EDITH GRISHMAN, M.D.
Immunofluorescence microscopy and electron microscopy are mutually complementary in the characterization of immune deposits in renal glomeruli. Deposits differ in  composition: various classes of immunoglobulins, components of complement, fibrinogen, and sometimes also specific antigens;  form: granular, nodular, linear;  location: mostly in the capillary wall (under the epithelium, under the endothelium, in the basement membrane) but sometimes also or predominantly in the mesangium;  ultrastructure: fine-grained, coarse-grained, "organized," virus-like. These features combine to form patterns that may be specific for particular glomerular diseases.
JACOB CHURG, EDITH GRISHMAN. Ultrastructure of Immune Deposits in Renal Glomeruli. Ann Intern Med. 1972;76:479–486. doi: 10.7326/0003-4819-76-3-479
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Published: Ann Intern Med. 1972;76(3):479-486.
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