RICHARD S. BORNSTEIN, M.D.; J. W. YARBRO, M.D., PH.D.; RICHMOND T. PREHN, M.D.
Extensive investigation of the immunology of animal neoplasia suggests that host immunity may be a factor of major importance in host resistance to cancer. Although data from humans provide less rigorous evidence, they suggest that man does respond immunologically to tumors. Selected reports (Table 1) indicate that both cellular immunity and circulating antibodies against human cancer have been demonstrated repeatedly by various techniques against a wide spectrum of tumors. Although these are by no means uniform phenomena, it seems probable, especially in malignant melanoma, that the host can mount an immune response against autochthonous neoplastic tissue. Furthermore, a variety of
BORNSTEIN RS, YARBRO JW, PREHN RT. Immunotherapy: The Need for Critical Studies. Ann Intern Med. ;76:499–501. doi: 10.7326/0003-4819-76-3-499
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Published: Ann Intern Med. 1972;76(3):499-501.
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