DWIGHT W. CLARK, M.D.; LEON I. GOLDBERG, Ph.D., M.D.
Guancydine was investigated as part of three antihypertensive regimens. In regimen I guancydine and the diuretic, quinethazone, were administered to five patients; their blood pressure decreased by an average of 34/28 mm Hg, in the supine position, and 32/28 mm Hg, in the erect position. In regimen II guancydine was administered to 10 patients receiving guanethidine (average dose, 49 mg/day) and quinethazone; their blood pressure decreased by 33/27 mm Hg, supine, and 20/25 mm Hg, erect. Guancydine was also given to eight patients receiving a larger dose of guanethidine (average dose, 234 mg/day) and quinethazone; their blood pressure decreased by 49/25 mm Hg, supine, and 47/23 mm Hg, erect. Similar reductions in the supine pressure occurred in regimen III, when propranolol was substituted for guanethidine in five patients, but orthostasis did not occur with propranolol as with guanethidine. Hyperexcitability in one patient and paresthesia in another required discontinuation of guancydine therapy. These results indicate that guancydine is an effective agent when used in combination with quinethazone, guanethidine, or propranolol.
CLARK DW, GOLDBERG LI. Guancydine: A New Antihypertensive Agent: Use with Quinethazone and Guanethidine or Propranolol. Ann Intern Med. ;76:579–585. doi: 10.7326/0003-4819-76-4-579
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Published: Ann Intern Med. 1972;76(4):579-585.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology, Rhythm Disorders and Devices.
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