JOEL S. BENNETT, M.D.; JAMES BOND, M.D.; IRWIN SINGER, M.D., F.A.C.P.; ARLAN J. GOTTLIEB, M.D.
Two patients with advanced Hodgkin's disease had persistent hypouricemia. Renal clearance studies showed elevated uric acid clearances of 35 and 23 ml/min, respectively. Only minimal abnormalities of other renal tubular functions were present. In both cases the abnormal renal handling of uric acid was corrected with therapy of the Hodgkin's disease, strongly suggesting that the disease was the causal factor. In one patient Hodgkin's disease and hypouricemia recurred, associated with a renal uric acid clearance of 20 to 25 ml/min, and studies with pyrazinamide were done. Assuming that pyrazinamide nearly completely blocks renal tubular secretion of uric acid in man, the study suggests that excessive secretion of uric acid was the cause of the serum and urine abnormalities.
BENNETT JS, BOND J, SINGER I, GOTTLIEB AJ. Hypouricemia in Hodgkin's Disease. Ann Intern Med. ;76:751–756. doi: 10.7326/0003-4819-76-5-751
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Published: Ann Intern Med. 1972;76(5):751-756.
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