CHARLES A. HALL, M.D.; MARY E. RAPPAZZO, M.S.
Deficiency of vitamin B12 (B-12) or folate produces morphologic abnormalities in all three of the most important cells of the blood (1). Precursors of erythrocytes are large in both nucleus and cytoplasm. The chromatin has an open pattern of fine meshwork. The production of hemoglobin is not normally synchronized with cell age. Granulocyte precursors are also large with large nuclei. Nuclei of the later stages are sometimes described as horseshoe-shaped, ribbon-like, or serpentine. Megakaryocytes, as well, show abnormalities in their appearance and lobulation. Peripherally, the erythrocytes are large, although there is a wide range in cell sizes, and the granulocytes
HALL CA, RAPPAZZO ME. Multiple Megaloblastosis. Ann Intern Med. ;76:826–827. doi: 10.7326/0003-4819-76-5-826
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Published: Ann Intern Med. 1972;76(5):826-827.
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