J. R. Givens, M.D.; W. L. Wiser, M.D.; R. N. Anderson, Ph.D.; R. S. Wilroy, M.D.; S. A. Coleman, M.D.; S. A. Fish, M.D.
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This study documented hyperandrogenism in 18 hirsute women and determined if the condition was gonadotropin dependent. Plasma androstenedione, testosterone, and luteinizing hormone (LH) were measured by radioimmunoassay. All had 24-hour urinary 17-ketosteroids, 17-ketogenic steroids, and pregnanetriol measured, and those with Cushing's syndrome and congenital adrenal hyperplasia we e excluded from the study. Six underwent bilateral longitudinal ovarian wedge resection and had polycystic ovarian disease. The mean plasma androstenedione of 18 patients was 332 ng/100 ml (SE ± 24.6 ng/100 ml). The normal mean androstenedione is 180 ng/100 ml. Mean plasma testosterone was 77 ng/100 ml (±12.2). The normal range for
J. R. Givens, W. L. Wiser, R. N. Anderson, R. S. Wilroy, S. A. Coleman, S. A. Fish. Suppression of Plasma Androstenedione and Testosterone in Hirsute Women.. Ann Intern Med. 1972;76:858. doi: 10.7326/0003-4819-76-5-858_1
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Published: Ann Intern Med. 1972;76(5):858.
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