Clarence Grim, M.D.; Thomas Peters, M.S.; John Maher, M.D., F.A.C.P.
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Low renin hypertension is characterized by normokalemia, suppressed plasma renin activity (PRA), and normal urinary aldosterone excretion (UA). To define further the pathophysiology of low renin hypertension, in six normal persons and five patients with low renin hypertension the authors measured the response of PRA (nanograms angiotensin I per milliliter per hour by radioimmunoassay) and plasma aldosterone (PA) (nanograms per 100 ml by radioimmunoassay) to  4-hour saline infusion (30 ml/kg body weight);  2-hour upright posture on high sodium intake (3 days);  2-hour upright posture on low sodium intake (3 days); and  condition 3 plus 1 day
Grim C, Peters T, Maher J. Low Renin Hypertension: A State of Inappropriate Secretion of Aldosterone.. Ann Intern Med. ;76:858. doi: 10.7326/0003-4819-76-5-858_2
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Published: Ann Intern Med. 1972;76(5):858.
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