Maurice E. Shils, M.D.
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Experimental human magnesium depletion resulted in the development of neurologic and gastrointestinal signs and symptoms and biochemical changes (SHILS ME: Medicine (Balt.) 48:61, 1969). An awareness developed of similar clinical and electrolyte changes occurring in patients with various diseases associated with hypomagnesemia. Most magnesium-depleted individuals are so ill that meaningful studies are not possible. Nine patients were studied, however, under relatively well-controlled conditions. A close resemblance was noted between the manifestations of clinical magnesium deficiency and those of experimental depletion. Marked hypomagnesemia was associated with hypocalcemia, hypokalemia, and hypocalciuria with one or more signs and symptoms including carpo-pedal spasm (without
Shils ME. Symptomatic Magnesium Deficiency—Clinical and Biochemical Aspects.. Ann Intern Med. ;76:859. doi: 10.7326/0003-4819-76-5-859_2
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Published: Ann Intern Med. 1972;76(5):859.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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