E. P. DiMagno, M.D.; V. L. W. Go, M.D.; W. H. J. Summerskill, M.D.
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To investigate the reserve capacity of the exocrine pancreas, the relationship of steatorrhea (fecal fat > 7 g/day) and creatorrhea (fecal nitrogen > 2.5 g/day) to lipase and trypsin outputs was studied in 17 patients with chronic pancreatitis and seven healthy subjects. Stools were collected for 48 hours while a standard diet was ingested. Total enzyme outputs in response to duodenal perfusion of essential amino acid (78 mM) and intravenously administered CCK-PZ (0.25 units/kg body weight·min) were compared in all patients and subjects by methods previously validated (Go et al., J Clin Invest 49:1558, 1970). Both reflex CCK-PZ and direct
DiMagno EP, Go VLW, Summerskill WHJ. Malabsorption Related to Total Enzyme Output in Chronic Pancreatitis.. Ann Intern Med. ;76:859. doi: 10.7326/0003-4819-76-5-859_3
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Published: Ann Intern Med. 1972;76(5):859.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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