J. I. Haft, M.D., F.A.C.P.; P. D. Kranz, M.D.; K. Gershengorn, M.D.; F. J. Albert, M.D.; R. Oestreicher, M.D.; K. Fani, M.D.
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Sympathetic catecholamines will cause aggregation of platelets in vitro. Infusion of catecholamines in the experimental animal will result in necrosis in the myocardium. In order to determine if this cardiac necrosis is caused in part by the intravascular aggregation of platelets, two studies involving pretreatment with drugs known to inhibit platelet aggregation and the electron microscopic demonstration of platelet thrombi in cardiac capillaries were undertaken.
Thirty dogs were infused with epinephrine 4 g/kg body weight·min for 4 hours. Ten were pretreated with aspirin, 10 gr b.i.d.; 10 with dipyridamole, 50 mg b.i.d., for 4 days; and 10 served as controls.
Haft JI, Kranz PD, Gershengorn K, Albert FJ, Oestreicher R, Fani K. Intravascular Platelet Aggregation on the Heart Induced In Vivo by Catecholamine Infusion.. Ann Intern Med. ;76:864–865. doi: 10.7326/0003-4819-76-5-864_4
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Published: Ann Intern Med. 1972;76(5):864-865.
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