Veterans Administration Drug Lipid Cooperative Study Group
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Five hundred seventy male veterans, average age 51 years, with documented transmural myocardial infarction occurring within a 12-month period, were randomized into groups receiving placebo, estrogen (1.25 mg Premarin® per day), dextrothyroxine (4 mg/day), aluminum nicotinate (Nicalex® 4 g/day), combined estrogen and nicotinate (full dosage of Premarin plus Nicalex), or combined estrogen and dextrothyroxine (full dosage of Premarin plus dextrothyroxine). Follow-up was 5 years; the interval between visits, 2 months. Adherence was carefully monitored. Dietary or smoking modifications were not stressed. Average baseline cholesterol was 241 mg/100 ml. Estrogen had no effect on cholesterol levels. Maximal drop in cholesterol was
. Failure of Cholesterol-Lowering Drugs to Influence Coronary Mortality: A Double Blind 5-Year Secondary Prevention Study.. Ann Intern Med. 1972;76:868. doi: 10.7326/0003-4819-76-5-868_3
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Published: Ann Intern Med. 1972;76(5):868.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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