Sherrill J. Slichter, M.D.; Laurence A. Harker, M.D.
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The modified template Ivy bleeding time was evaluated as a test of in vivo platelet function in 79 selected patients with acquired and genetic platelet dysfunction. The bleeding time in 100 normal subjects averaged 4.5 minutes ± 1.7 (± 1 SD). In studies with aspirin, phenylbutazone, paraproteinemia, uremia, and von Willebrand's disease, prolongation of the bleeding time was both a more sensitive and reproducible test than a battery of in vitro function tests that included collagen adhesion; aggregation with adenosine diphosphate, adrenalin, collagen, thrombin; glass bead retention; platelet factor 3 (phospholipid); and clot retraction.
In 27 patients with hypoproliferative thrombocytopenia,
Slichter SJ, Harker LA. The Standardized Bleeding Time as a Measure of Platelet Function In Vivo.. Ann Intern Med. ;76:871. doi: 10.7326/0003-4819-76-5-871_1
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Published: Ann Intern Med. 1972;76(5):871.
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