J. V. Donadio, M.D., F.A.C.P.; R. D. Wagoner, M.D., F.A.C.P.; R. H. Ferguson, M.D., F.A.C.P.; F. C. McDuffie, M.D., F.A.C.P.; K. E. Holley, M.D.
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It is unclear whether treatment of patients with lupus nephritis with combined corticoid and cytotoxic drugs is more effective than treatment with corticoids alone. Two treatment programs were evaluated for 6 months in patients with active lupus glomerulonephritis. Group A (9 patients) received prednisone (mean, 40 mg/day) and Group B (7 patients) received prednisone (same dosage) and azathioprine (2 to 3 mg/kg body weight-day). Renal biopsy activity was scored by a semiquantitative method based on the presence and extent of glomerular proliferation, necrosis, karyorrhexis, fibrinoid deposition, hyaline thrombi, and vasculitis. According to activity scores patients were randomly assigned to Group
Donadio JV, Wagoner RD, Ferguson RH, McDuffie FC, Holley KE. Treatment of Patients with Lupus Nephritis with Prednisone and Combined Prednisone-Azathioprine.. Ann Intern Med. ;76:873–874. doi: 10.7326/0003-4819-76-5-873_4
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Published: Ann Intern Med. 1972;76(5):873-874.
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