J. M. Lazarus, M.D.; C. L. Hampers, M.D.; J. P. Merrill, M.D.
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A group of patients were on hemodialysis with persistent hypertension despite maximum ultrafiltration and bilateral nephrectomy. In a pilot study of 140 hemodialysis patients, an increased frequency and severity of postural hypotension was found in hypertensive uremic patients and suggests an abnormality in the baroreceptor mechanism. To further evaluate a "resetting" of the baroreceptor mechanism the effects of standing and drug-induced blood pressure changes were serially studied in four normotensive and nine hypertensive (> 150/90 mm Hg) patients before and after nephrectomy. Baroreceptor function was evaluated by the pulse response to elevation and lowering of blood pressure with angiotensin and
Lazarus JM, Hampers CL, Merrill JP. Baroreceptor Function in Hypertensive and Normotensive Patients with Uremia.. Ann Intern Med. ;76:875. doi: 10.7326/0003-4819-76-5-875_1
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Published: Ann Intern Med. 1972;76(5):875.
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