William J. Mroczek, M.D.; Michael Davidov, M.D.; Frank A. Finnerty Jr., M.D.
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The relative efficacy of Clonidine and methyldopa, each combined with a diuretic, was studied in 41 outpatients with moderately severe or severe hypertension. The antihypertensive effect of each combination was compared with that of the diuretic alone. After a control period, all patients received chlorthalidone for 3 weeks. An antihypertensive drug was then added in a double-blind, randomized, crossover fashion. Either Clonidine hydrochloride, 0.45 mg, or methyldopa, 750 mg, was given daily in three divided oral doses. After 12 weeks, patients received the alternate antihypertensive for a similar period. Compared to base-line, all three treatments reduced the blood pressure to
Mroczek WJ, Davidov M, Finnerty FA. A Double-Blind Comparison of Clonidine and Methyldopa in Hypertensive Patients.. Ann Intern Med. ;76:875. doi: 10.7326/0003-4819-76-5-875_2
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Published: Ann Intern Med. 1972;76(5):875.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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