Charles E. Jackson, M.D., F.A.C.P.; Armen H. Tashjian Jr., M.D.; Melvin A. Block, M.D.
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Radioimmunoassay of calcitonin is a reliable and practical means for early detection of medullary thyroid cancer, often before any other procedure indicates its presence. Response of serum calcitonin to calcium infusion was utilized as a diagnostic procedure in 58 members of three families with medullary thyroid carcinoma. Elevated basal or calcium stimulated levels, or both, were obtained in 16 individuals in these families. All 13 who subsequently had surgery were found to have bilateral neoplasms, the extent correlating well with stimulated calcitonin levels. These studies served as the only indication for surgery in the seven patients without palpable lesions. The
Jackson CE, Tashjian AH, Block MA. Detection of Medullary Thyroid Cancer by Calcitonin Assay in Families.. Ann Intern Med. 1972;76:877. doi: 10.7326/0003-4819-76-5-877_1
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Published: Ann Intern Med. 1972;76(5):877.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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