Anne J. Krush, M.S.; Henry T. Lynch, M.D.
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The cancer family syndrome is characterized by  increased occurrences of adenocarcinoma predominantly adenocarcinoma of the colon, stomach, and endometrium;  an excess of multiple primary malignant neoplasms;  early age of onset of cancer; and  probable autosomal dominant inheritance. Eight families studied during the past 8 years showed the above criteria. Analyses were made of all varieties of malignant neoplasms in the kindreds and compared with the prevalence of comparable cancers from the New York State Tumor Registry (exclusive of New York City) and compared similarly with tumor expectations including all the known varieties of hereditary cancers. Cancer
Krush AJ, Lynch HT. Differential Diagnosis of the Cancer Family Syndrome.. Ann Intern Med. ;76:877–878. doi: 10.7326/0003-4819-76-5-877_3
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Published: Ann Intern Med. 1972;76(5):877-878.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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