Richard W. Light, M.D.; Isabelle MacGregor, M.D.; Wilmot C. Ball Jr., M.D.; Peter C. Luchsinger, F.A.C.P.
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Traditionally, a pleural-fluid protein level of 3 g has been used to separate transudates from exudates, but this resulted in the wrong classification of 15% of the effusions. Recently, the lactic acid dehydrogenase (LDH) level of the pleural fluid has been proposed as the better discriminator. The utility of these two methods along with protein electrophoresis and LDH isozymes were evaluated in a prospective study of 149 pleural effusions. Using preset diagnostic criteria, 47 transudates and 102 exudates including 25 parapneumonic, 14 tuberculous, 43 malignant, and 20 miscellaneous effusions were studied. When a protein level of 3 g was used
Light RW, MacGregor I, Ball WC, Luchsinger PC. Pleural-Fluid Lactic Acid Dehydrogenase and Protein Content.. Ann Intern Med. ;76:880. doi: 10.7326/0003-4819-76-5-880_2
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Published: Ann Intern Med. 1972;76(5):880.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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