MAXWELL FINLAND, M.D., M.A.C.P.
Groups of strains of selected bacterial pathogens were collected at intervals from patients at Boston City Hospital and tested for susceptibility to antibiotics, using essentially the same method throughout. Group A hemolytic streptococci, pneumococci, gonococci, meningococci, and Hemophilus influenzae have generally shown no tendency to increased resistance. Exceptions were the increased resistance of some groups A and B streptococci and pneumococci to tetracyclines, the gradually increasing resistance of gonococci to penicillin, and the widespread sulfonamide resistance of meningococci. Of importance has been the steadily increasing resistance of staphylococci to many antibiotics through the 1950s, with evidence of reversal since then. Most important has been the increasing resistance of common Gram-negative bacilli (Escherichia coli, Proteus, Klebsiella, Enterobacter, Serratia and Pseudomonas) to the most widely used antibiotics. Reversal of these trends may result from limiting use of antibiotics and immunosuppressives to essential and rational therapy, holding some active antibiotics in reserve, and improving surgical techniques.
MAXWELL FINLAND. Changing Patterns of Susceptibility of Common Bacterial Pathogens to Antimicrobial Agents. Ann Intern Med. 1972;76:1009–1036. doi: 10.7326/0003-4819-76-6-1009
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Published: Ann Intern Med. 1972;76(6):1009-1036.
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