E. G. KING, M.D., F.A.C.P.; M. E. CLARKE, M.D.; D. I. BUCHANAN, M.D.
To the editor: Commercial factor VIII concentrates of pooled plasma origin are being used increasingly in minor and major replacement therapy of hemophilia A bleeding episodes. A case has drawn to our attention that significant isoantibody infusion may occur in replacement and produce acute anemia.
Patient D.H., an 18-year-old man with hemophilia A underwent emergency cricothyrotomy and tracheotomy 15 December 1971 for gross respiratory distress from a cough-produced paralaryngeal hematoma. On the day of surgery the patient received 28 units of group-specific cryoprecipitate, and for 10 days thereafter he was maintained on 18 to 30 cryoprecipitate units/day. Antihemophilic globulin concentrate
KING EG, CLARKE ME, BUCHANAN DI. Acute Anemia with Factor VIII Therapy. Ann Intern Med. ;77:323–324. doi: 10.7326/0003-4819-77-2-323
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Published: Ann Intern Med. 1972;77(2):323-324.
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