STANLEY VERMILLION, M.D.
To the editor: The case report by Dr. McPhedran and colleagues (1) describing an "alpha-2 spike" in a case of renal carcinoma was of considerable interest to me. The alpha-2 globulin elevation, in association with renal malignancies, has been recognized for several years; that haptoglobin composes most of this elevation is a more recent observation. Stauffer (2) described a syndrome of nephrogenic hepatic dysfunction in 1961. This syndrome was characterized by an increase in the alkaline phosphatase value, thymol turbidity, sulfobromophthalein retention, and an increase in alpha-2 globulin that was reversible with removal of the tumor. Utz and co-workers described
VERMILLION S. Renal Carcinoma and Alpha-2 Globulin. Ann Intern Med. ;77:324–325. doi: 10.7326/0003-4819-77-2-324_2
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Published: Ann Intern Med. 1972;77(2):324-325.
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