FRANK A. OSKI, M.D.; BERTRAM LUBIN, M.D.; EILEEN DOBER BUCHERT, R.N.
Women taking oral contraceptives had red cells with decreased filterability. The mean half-life for red cell filtration was 6.23 minutes in 34 such women, as contrasted with 4.16 minutes in 36 control women. Within 2 to 3 days of discontinuing therapy the filterability improved significantly. Similar changes in red cell filtration were produced in four male volunteers. These changes occured within 1 to 3 days of the initiation of therapy with a combination of norethindrone and mestranol. It is proposed that the red cell rigidity produced by the ingestion of oral contraceptives may produce stasis in the microcirculation, which might ultimately lead to thrombosis.
OSKI FA, LUBIN B, BUCHERT ED. Reduced Red Cell Filterability with Oral Contraceptive Agents. Ann Intern Med. ;77:417–419. doi: 10.7326/0003-4819-77-3-417
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Published: Ann Intern Med. 1972;77(3):417-419.
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