EZRA SHARON, M.D.; JAMES S. PAOLINO, M.D.; DAVID KAPLAN, M.D.
To the editor: The efficacy of intra-arterial reserpine in the treatment of patients with Raynaud's phenomenon has been shown (1-3). The reported side effects related to this treatment were usually mild; the expected systemic features, such as hypotension, bradycardia, and nasal stiffness, were rarely encountered.
We recently treated 12 patients who had scleroderma and Raynaud's phenomenon with an injection of 1 mg of reserpine into a brachial artery. Side effects included transient hypotension (2 cases), mild depression (1 case), and an episode of hematemesis within 2 hours of the intra-arterial injection (2 cases). Hematemesis after intra-arterial reserpine has not been
SHARON E, PAOLINO JS, KAPLAN D. Hematemesis After Reserpine for Raynaud's Phenomenon. Ann Intern Med. ;77:479–480. doi: 10.7326/0003-4819-77-3-479
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Published: Ann Intern Med. 1972;77(3):479-480.
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