HARVEY J. ALTER, M.D.; PAUL V. HOLLAND, M.D.; ROBERT H. PURCELL, M.D.; JERROLD J. LANDER, M.D.; STEPHEN M. FEINSTONE, M.D.; ANDREW G. MORROW, M.D.; PAUL J. SCHMIDT, M.D.
In a prospective study the exclusion of commercial blood donors and donors positive for hepatitis-B antigen (HBAg) resulted in a hepatitis frequency of only 3.7 cases/1000 units transfused. Residual posttransfusion hepatitis was caused by at least two viruses. Four of 10 cases were short incubation, HBAg negative; six cases were long incubation, HBAg positive. One patient had both diseases in sequence. Some cases of HBAg-positive hepatitis occurred despite the fact that patients received only blood that was HBAg negative by counterelectrophoresis; current tests for HBAg, including radioimmunoassay, cannot detect all donors capable of transmitting HBAg-positive hepatitis. The presence of anti-HBAg in donor blood was common and did not correlate with posttransfusion hepatitis; donors with anti-HBAg should not be excluded.
HARVEY J. ALTER, PAUL V. HOLLAND, ROBERT H. PURCELL, JERROLD J. LANDER, STEPHEN M. FEINSTONE, ANDREW G. MORROW, et al. Posttransfusion Hepatitis After Exclusion of Commercial and Hepatitis-B Antigen-Positive Donors. Ann Intern Med. 1972;77:691–699. doi: 10.7326/0003-4819-77-5-691
Download citation file:
Published: Ann Intern Med. 1972;77(5):691-699.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use