WILLIAM S. HUGHES, M.D.; FRANK P. BROOKS, M.D.; HAROLD O. CONN, M.D.
Fasting serum gastrin levels were measured in 12 adults with primary hypogammaglobulinemia, 15 patients with primary pernicious anemia, and control subjects. Five of the patients with primary hypogammaglobulinemia had pernicious anemia. The fasting serum gastrin level in patients with primary hypogammaglobulinemia and pernicious anemia (74 ± 20 pg/ml [mean ± SE]) was significantly lower (P < 0.001) than the level in patients with primary pernicious anemia (1336 ± 189 pg/ml). The gastrin levels in hypogammaglobulinemic patients with pernicious anemia (74 ± 20 pg/ml) and without pernicious anemia (72 ± 12 pg/ml) were similar to the level in normal age-matched (41 to 50 years) control subjects (89 ± 11 pg/ml). The new finding of normal fasting serum gastrin levels in patients with hypogammaglobulinemia and pernicious anemia suggests that, in contrast to the gastric lesion in primary pernicious anemia, the gastric lesion in primary hypogammaglobulinemia involves the gastrin-producing cells of the gastric antrum as well as the parietal cells of the gastric body and fundus.
WILLIAM S. HUGHES, FRANK P. BROOKS, HAROLD O. CONN. Serum Gastrin Levels in Primary Hypogammaglobulinemia and Pernicious Anemia: Studies in Adults. Ann Intern Med. 1972;77:746–750. doi: 10.7326/0003-4819-77-5-746
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Published: Ann Intern Med. 1972;77(5):746-750.
Hematology/Oncology, Red Cell Disorders.
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