Two papers appearing in a recent issue of the British Medical Journal raise serious doubts about the validity of the current American approach to Hodgkin's disease. Halie and associates (1, 2) make two major points in these papers. First, they describe an abnormal basophilic leukocyte in peripheral blood concentrates from Hodgkin's patients, which they believe indicates dissemination of the disease to the spleen. Second, they propose that splenic lymphoma, as evidenced by these abnormalities, signifies hematogenous spread and that patients with such spread are not properly classified by current staging systems and do poorly after radiation therapy.
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Hematogenous Dissemination of Hodgkin's Disease. Ann Intern Med. 1972;77:810–811. doi: 10.7326/0003-4819-77-5-810
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Published: Ann Intern Med. 1972;77(5):810-811.
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