DONALD P. SCHLUETER, M.D.; JORDAN N. FINK, M.D.; GEORGE T. HENSLEY, M.D.
Respiratory disease resulting from prolonged exposure to logs contaminated with Alternaria may be owing to a hypersensitivity reaction. Two patients had heavy and prolonged exposure to this mold during the manufacture of wood pulp. Their exposure led to recurrent episodes of chills, fever, and dyspnea that were followed by irreversible alterations in pulmonary function. Lung biopsy specimens showed changes compatible with a hypersensitivity pneumonitis. An inhalation challenge with an extract of Alternaria reproduced the clinical features of their disease.
SCHLUETER DP, FINK JN, HENSLEY GT. Wood-Pulp Workers' Disease: A Hypersensitivity Pneumonitis Caused by Alternaria. Ann Intern Med. ;77:907–914. doi: 10.7326/0003-4819-77-6-907
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Published: Ann Intern Med. 1972;77(6):907-914.
Infectious Disease, Interstitial Lung Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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