CARL R. KJELDSBERG, M.D.; HARRY P. WARD, M.D., F.A.C.P.
Aplastic anemia developed in a 67-year-old man after many months' use of arsenic-containing pesticides. He was treated with penicillamine and oxymetholone, which promptly restored his blood count to normal limits. Three months later he again had aplastic anemia, and the urine once more contained considerable amounts of arsenic. Treatment with pencillamine and oxymetholone was reinstituted. This resulted in excellent urinary excretion of arsenic, but his blood count did not improve. Five months after pancytopenia first developed, he had acute myelogenous leukemia, which was treated with prednisone, cytosine arabinoside, and thioguanine. This had no beneficial effects, and he died of klebsiella septicemia. Autopsy showed widespread leukemic infiltrates.
KJELDSBERG CR, WARD HP. Leukemia in Arsenic Poisoning. Ann Intern Med. ;77:935–937. doi: 10.7326/0003-4819-77-6-935
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Published: Ann Intern Med. 1972;77(6):935-937.
Emergency Medicine, Hematology/Oncology, Leukemia/Lymphoma, Neurology.
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