WILLIAM C. WEESE, M.D.; RONALD W. SCHOPE, M.D.
To the editor: Recent articles in the ANNALS OF INTERNAL MEDICINE have emphasized clinical usefulness of 5-fluorocytosine in the treatment of fungal diseases. In two, therapeutic failure due to drug resistance in cryptococcal meningitis was suggested, although not documented (1, 2). A third paper (3) reported resistant strains of Cryptococcus neoformans mainly in patients receiving less than 100 mg/kg body weight of 5-fluorocytosine daily. None observed thrombocytopenia. We wish to report a patient with cryptococcal meningitis in whom both drug resistance and thrombocytopenia developed during 5-fluorocytosine therapy.
A 43-year-old white man with chronic glomerulonephritis had undergone splenectomy, bilateral nephrectomy, and
WEESE WC, SCHOPE RW. 5-Fluorocytosine Therapy. Ann Intern Med. ;77:1003–1004. doi: 10.7326/0003-4819-77-6-1003
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Published: Ann Intern Med. 1972;77(6):1003-1004.
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