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This monograph is meant to review comprehensively our current knowledge of the physiological and pathological alterations of p-hydroxyphenylpyruvate oxidase activity and the resultant changes in tyrosine catabolism. Initially, the author succinctly describes the overall pathway for the biological oxidation of phenylalanine and tyrosine to fumarate and acetoacetate. The second chapter focuses on the biochemical characteristics of one step in this pathway, the conversion of p-hydroxyphenylpyruvate to homogentisate by p-hydroxyphenylpyruvate oxidase. There is an excellent summary of the postulated mechanisms of action, assay, physical properties, co-factors, and inhibitors of this enzyme. The second half of the monograph is devoted to clinical
Tyrosine Catabolism: The Biological, Physiological, and Clinical Significance of p-Hydroxyphenylpyruvate Oxidase.. Ann Intern Med. 1972;77:1013. doi: 10.7326/0003-4819-77-6-1013_2
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Published: Ann Intern Med. 1972;77(6):1013.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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