ROBERT A. O'REILLY, M.D., F.A.C.P.
To evaluate the interaction of sodium warfarin and disulfiram (Antabuse®), a single dose (1.5 mg/kg body weight) and a 21-day course of sodium warfarin were administered orally, with and without disulfiram orally, to eight normal subjects. A significant augmentation of both the hypoprothrombinemia (P < 0.01) and the plasma warfarin level (P < 0.05) occurred with daily disulfiram compared with warfarin alone, for both the single-dose and 21-day experiments. In the single-dose and 21-day experiments a highly significant correlation of the changes in plasma warfarin levels and in the hypoprothrombinemia occurred, which was positive in 13 and negative in 2 experiments. We conclude that disulfiram increases the anticoagulant effect of warfarin therapy in most but not all subjects by inhibiting its metabolism in the liver. An augmentation of the therapeutic effect of a drug by disulfiram has thus been shown for the first time in humans.
O'REILLY RA. Interaction of Sodium Warfarin and Disulfiram (Antabuse®) in Man. Ann Intern Med. ;78:73–76. doi: 10.7326/0003-4819-78-1-73
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Published: Ann Intern Med. 1973;78(1):73-76.
Coagulopathies, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease.
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