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The initial 87 pages of this extensive review on haptoglobin (Hp) emphasize biochemistry. Jayle and associates quite correctly are credited with discovering this glycoprotein (1938) and Smithies with noting its first human allotypes (1955). Subsequent chapters examine the isolation of haptoglobin, the chemical structure of its alpha (α) and beta (β) chains, hapto-hemoglobin complexes, the quantitation, and finally the qualitation of haptoglobin.
These introductory chapters are well composed but are often overly detailed. They contain information more valuable to an investigator in haptoglobin chemistry and physiology than to other physicians. But interspersed among the detail are many useful and pertinent
The Biochemical, Genetic, and Clinicopathological Aspects of Haptoglobin.. Ann Intern Med. ;78:164–165. doi: 10.7326/0003-4819-78-1-164
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Published: Ann Intern Med. 1973;78(1):164-165.
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