CHESTER A. ALPER, M.D.
It is almost a decade since genetic deficiency of alpha-1 antitrypsin was discovered in Malmö, Sweden, by Laurell and Eriksson (1) and shown to be associated with a tendency to early-onset chronic obstructive pulmonary disease. As is so often the case, studies over the intervening years have shown the matter to be more complex than in its original conception. At least 13 genes occur at an autosomal locus (designated Pi for protease inhibitor) that controls the production of alpha-1 antitrypsin (2). These alleles are recognized by the different mobilities of their products on electrophoresis of serum. A few of these
ALPER CA. Deficiency of Alpha-1 Antitrypsin. Ann Intern Med. ;78:298–299. doi: 10.7326/0003-4819-78-2-298
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Published: Ann Intern Med. 1973;78(2):298-299.
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