SHELDON P. BLAU, M.D.
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To the editor: I read with interest the review on recent advances in rheumatoid diseases (Ann Intern Med 77:455-464, 1972). I was particularly impressed by the statement, "antibodies against DNA . . . seem to be quite specific for human systemic lupus erythematosus." It would appear that this is a generalization and is not correct.
To begin, in the ANNALS OF INTERNAL MEDICINE, 76: 365-374, 1972, Hahn and others have shown that hydralazine-induced lupus may elicit the formation of anti-DNA antibodies in significant titer. In addition, I have extensive personal experience with the Farr method for measuring antibodies to DNA.
BLAU SP. Anti-DNA Antibodies: Specificity?. Ann Intern Med. ;78:308. doi: 10.7326/0003-4819-78-2-308_2
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Published: Ann Intern Med. 1973;78(2):308.
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