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Because of advances in the understanding of the relation between the structure of proteins and their function, mechanisms of enzyme action, and the regulation of the activities of enzymes over both short and long time scales, it is now possible, conceptually at least, to begin to consider the diagnosis and therapy of diseases in terms of chemical mechanisms. This, in fact, is the logical extension of the problem-oriented approach to diagnosis and treatment. The perspective from which the book was written seems to be that it is now possible to formulate chemical models for clinically observed disorders of the function
The Human Adipose Cell: A Model for Errors in Metabolic Regulation.. Ann Intern Med. ;78:322. doi: 10.7326/0003-4819-78-2-322_2
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Published: Ann Intern Med. 1973;78(2):322.
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