JAMES W. SMITH, M.D.
Amphotericin B has been the drug of choice for most of the systemic fungal infections for 15 years. Its efficacy in certain of these infections with high case-fatality rates has been clearly established. Nevertheless, the difficulties that arise with its administration—delay in its action in seriously ill persons, varous major toxic effects, and the difficulties of administering it—are formidable problems. Another recently approved agent, 5-fluorocytosine, is efficacious for candidal and cryptococcal infections, but resistance to it has been noted in treated patients. Consequently, the recent reports of synergistic activity of amphotericin B with various other drugs, by Kobayashi and associates
SMITH JW. Synergism of Amphotericin B with Other Antimicrobial Agents. Ann Intern Med. ;78:450. doi: 10.7326/0003-4819-78-3-450
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Published: Ann Intern Med. 1973;78(3):450.
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