THOMAS J. DEGNAN, M.D., F.A.C.P.; VYDA PETZOLD, M.D.; ALLAN PUTTERMAN, M.D.
To the editor: We wish to report a severe hemolytic transfusion reaction from an extremely small amount of blood—specifically, 50 ml. The reaction was characterized by intravascular hemolysis, renal failure, and disseminated intravascular clotting; the latter was successfully treated with heparin.
A 34-year-old white woman was admitted because of vaginal bleeding associated with an incomplete abortion. She was initially reported as having group A (negative) blood; transfusion of one unit of A negative compatible blood was begun. After receiving 50 ml, the patient became cyanotic and acutely dyspneic and complained of backache. The transfusion was stopped, and posttransfusion study showed
DEGNAN TJ, PETZOLD V, PUTTERMAN A. Small Transfusion, Severe Reaction. Ann Intern Med. ;78:452–453. doi: 10.7326/0003-4819-78-3-452
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Published: Ann Intern Med. 1973;78(3):452-453.
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