CARL F. STRAUSS, M.D.
To the editor: Chlorpropamide is useful in diabetes insipidus for reduction of free water clearance (1), but there have also been reports of water intoxication and low-sodium syndromes with its use as a hypoglycemic agent (2, 3). Because angina frequently accompanies diabetes mellitus, aggravation of heart disease while the patient is receiving chlorpropamide takes on added significance. We have had the opportunity to observe this situation.
The patient was a 76-year-old white man with angina of two types: classical angina of exertion, retrosternal in location, crushing in character, and aggravated by eating and exposure to cold air; and angina occurring
STRAUSS CF. Chlorpropamide and Angina Pectoris. Ann Intern Med. 1973;78:454–455. doi: 10.7326/0003-4819-78-3-454_2
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Published: Ann Intern Med. 1973;78(3):454-455.
Cardiology, Coronary Heart Disease.
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