ROBERT D. GILBERT, M.D.
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To the editor: The report of Miller and Moses (Ann Intern Med 77:715-721, 1972) documenting the usefulness of the radioimmunoassay of urinary antidiuretic hormone (ADH) was impressive. But their data do not support their conclusion, as paraphrased in their abstract: "The urinary ADH response to water loading allows the certain diagnosis of inappropriate ADH syndrome. . . ." Although the antidiuretic hormone excretion was dramatically different from "normal" in their patients with the syndrome, no data on patients with hyponatremia and congestive heart failure, myxedema, or cirrhosis were presented. In fact, these diagnoses were rightly excluded on clinical grounds from
GILBERT RD. Inappropriate Antidiuretic Hormone. Ann Intern Med. ;78:462. doi: 10.7326/0003-4819-78-3-462_1
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Published: Ann Intern Med. 1973;78(3):462.
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