M. JEFFREY FRANK, M.D.; NATHAN FRANK, M.D., F.A.C.P.
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To the editor: To date a few pharmacologic agents have been found that effectively prevent the aggregation and reduce the "stickiness" of platelets: dipyridamole, Malayan cobra snake venom, and aspirin. To prove the efficacy of these drugs for prophylaxis of coronary artery thrombosis would require a trial of large numbers of patients over a period of several years. Valuable time lost! There is an indirect means that may help convince competent cardiac investigators that aspirin therapy is worthy for treatment of patients with potential or established ischemic heart disease due to coronary artery disease.
We suggest a study on this
FRANK MJ, FRANK N. Prophylactic Aspirin?. Ann Intern Med. ;78:462. doi: 10.7326/0003-4819-78-3-462_2
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Published: Ann Intern Med. 1973;78(3):462.
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