A. K. KHACHADURIAN, M.D.; M. J. ARSLANIAN, Ph.D.
A 57-year-old healthy man had a plasma uric acid level of 0.2 to 0.58 mg/100 ml. The 24-hour urinary urate excretion was normal, at 797 mg. Urate clearance was 48% higher than endogenous creatinine clearance. Urinary xanthine and hypoxanthine levels were at the upper limit of normal. There was no evidence of phosphaturia, glucosuria, or aminoaciduria. A 10-year-old son of his maternal cousin had a plasma urate level of 1.2 mg/100 ml and a urate clearance equal to 42% of endogenous creatinine clearance. The findings in this subject could be accounted for by an isolated defect of tubular urate reabsorption or a tubular mechanism for urate secretion.
KHACHADURIAN AK, ARSLANIAN MJ. Hypouricemia due to Renal Uricosuria: A Case Study. Ann Intern Med. ;78:547–550. doi: 10.7326/0003-4819-78-4-547
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Published: Ann Intern Med. 1973;78(4):547-550.
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