WILLIAM R. GRISWOLD, M.D.; GILBERT SIMON, M.D.; RAWLE M. MCINTOSH, M.D.
To the editor: Anaphylactoid pupura (Henoch-Schönlein purpura) is a syndrome of nonthrombocytopenic purpura, arthralgia, abdominal pain, gastrointestinal bleeding, and nephropathy. The cause is unknown, but immunologic and hematologic mechanisms seem to be involved. Recently we have observed a boy with this syndrome whose symptoms exacerbated after exposure to cold. Examination of his plasma showed cryofibrinogenemia.
This 4-year-old boy developed a mild urticarial and purpuric rash after cold exposure. One week later, while playing in the snow for an entire afternoon, he developed ecchymotic lesions on the legs and buttocks, pedal edema, and severe arthralgias of the knees and ankles. He
GRISWOLD WR, SIMON G, MCINTOSH RM. Anaphylactoid Purpura, Cold Exposure, and Cryofibrinogenemia. Ann Intern Med. ;78:611. doi: 10.7326/0003-4819-78-4-611_1
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Published: Ann Intern Med. 1973;78(4):611.
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